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Assessment of 2′-Fucosyllactose and Lacto-N-Neotetraose Solution as an Irrigant in E. faecalis-Infected Root Canals: An In Vitro Study

Authors :
Francesco Puleio
Rosario Pirri
Vincenzo Tosco
Angelo Sergio Lizio
Paola Tripodi
Isabella La Spina
Vincenza La Fauci
Raffaele Squeri
Source :
Clinics and Practice, Vol 14, Iss 4, Pp 1348-1356 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Background: Given the lack of an ideal endodontic irrigant on the market, this study evaluates the antimicrobial potential of a formulated solution of 2′-fucosyllactose and lacto-N-neotetraose against E. faecalis within infected root canals, and explores any associated impacts related to the duration of irrigation. Methods: 32 single-rooted teeth extracted for periodontal reasons were infected with Enterococcus faecalis, and subsequently subjected to endodontic treatment with two different irrigation systems: sodium hypochlorite or a solution of 2′-fucosyllactose and lacto-N-neotetraose. These samples were then incubated in sterile culture media at 37 °C to observe microbial activity through turbidity. The culture broth of each individual sample was assessed as positive or negative by observing the turbidity or lack of turbidity in the culture at the time of evaluation. Results: the analysis of the results obtained from the comparison of groups irrigated with sodium hypochlorite or a solution of 2′-fucosyllactose and lacto-N-neotetraose demonstrates that the case solution has no bactericidal effect against E. faecalis inoculated in the endodontic system. Conclusions: the HMOs used in this study do not have a bactericidal effect on E. faecalis inoculated in an endodontic system.

Details

Language :
English
ISSN :
20397283
Volume :
14
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Clinics and Practice
Publication Type :
Academic Journal
Accession number :
edsdoj.9846c81b7e7b4365a30c623fc1d814a0
Document Type :
article
Full Text :
https://doi.org/10.3390/clinpract14040108