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Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

Authors :
Raffaele Simeoli
Karli Montague
Hefin R. Jones
Laura Castaldi
David Chambers
Jayne H. Kelleher
Valentina Vacca
Thomas Pitcher
John Grist
Hadil Al-Ahdal
Liang-Fong Wong
Mauro Perretti
Johnathan Lai
Peter Mouritzen
Paul Heppenstall
Marzia Malcangio
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Exosomes are known to contain microRNAs (miRs). Here the authors show that dorsal root ganglion neurons release exosomes containing miR-21-5p, which contributes to inflammatory cell recruitment following peripheral nerve injury.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.985f58856e554adfb658898c61646afe
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-01841-5