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Chaotic Model of Brownian Motion in Relation to Drug Delivery Systems Using Ferromagnetic Particles

Authors :
Saša Nježić
Jasna Radulović
Fatima Živić
Ana Mirić
Živana Jovanović Pešić
Mina Vasković Jovanović
Nenad Grujović
Source :
Mathematics, Vol 10, Iss 24, p 4791 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Deterministic and stochastic models of Brownian motion in ferrofluids are of interest to researchers, especially those related to drug delivery systems. The Brownian motion of nanoparticles in a ferrofluid environment was theoretically analyzed in this research. The state of the art in clinical drug delivery systems using ferromagnetic particles is briefly presented. The motion of the nanoparticles in an external field and as a random variable is elaborated by presenting a theoretical model. We analyzed the theoretical model and performed computer simulation by using Maple software. We used simple low-dimensional deterministic systems that can exhibit diffusive behavior. The ferrofluid in the gravitational field without the presence of an external magnetic field in the xy plane was observed. Control parameter p was mapped as related to the fluid viscosity. Computer simulation showed that nanoparticles can exhibit deterministic patterns in a chaotic model for certain values of the control parameter p. Linear motion of the particles was observed for certain values of the parameter p, and for other values of p, the particles move randomly without any rule. Based on our numerical simulation, it can be concluded that the motion of nanoparticles could be controlled by inherent material properties and properties of the surrounding media, meaning that the delivery of drugs could possibly be executed by a ferrofluid without an exogenous power propulsion strategy. However, further studies are still needed.

Details

Language :
English
ISSN :
22277390
Volume :
10
Issue :
24
Database :
Directory of Open Access Journals
Journal :
Mathematics
Publication Type :
Academic Journal
Accession number :
edsdoj.988e22c3ab4843238b9e13386f6961e6
Document Type :
article
Full Text :
https://doi.org/10.3390/math10244791