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New Approved Drugs Appearing in the Pharmaceutical Market in 2022 Featuring Fragments of Tailor-Made Amino Acids and Fluorine

Authors :
Nana Wang
Haibo Mei
Gagan Dhawan
Wei Zhang
Jianlin Han
Vadim A. Soloshonok
Source :
Molecules, Vol 28, Iss 9, p 3651 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

The strategic fluorination of oxidatively vulnerable sites in bioactive compounds is a relatively recent, widely used approach allowing us to modulate the stability, bio-absorption, and overall efficiency of pharmaceutical drugs. On the other hand, natural and tailor-made amino acids are traditionally used as basic scaffolds for the development of bioactive molecules. The main goal of this review article is to emphasize these general trends featured in recently approved pharmaceutical drugs.

Details

Language :
English
ISSN :
14203049
Volume :
28
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.98fef407f3c540a8bf4f72004a9b6444
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules28093651