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Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- PFKFB3 enhances glycolysis to promote cancer cell proliferation. Here, the authors identify a long noncoding RNA in esophageal squamous cell carcinoma, AGPG, which interacts with PFKFB3 and promotes its stability, leading to increased glycolysis and proliferation.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 92252788
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.991c7443503b477c92252788160db378
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-15112-3