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Direct genome-wide identification of G-quadruplex structures by whole-genome resequencing

Authors :
Jing Tu
Mengqin Duan
Wenli Liu
Na Lu
Yue Zhou
Xiao Sun
Zuhong Lu
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Current methods to identify G-quadruplex structures in DNA require specialized protocols and multiple rounds of sequencing. Here, the authors develop a method to detect G-quadruplex structures in DNA based on fluctuations in sequencing quality in a standard sequencing experiment.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.992319cdcbdd4f78a6d4bd882d1279a6
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-26312-w