Evaluation of clopidogrel response in healthy cats using a novel viscoelastic test and thromboelastography

IntroductionCats with cardiomyopathy face an increased risk of arterial thromboembolism (ATE). Although clopidogrel is frequently utilized to mitigate this risk, feline responses to this therapy exhibit variability. This study evaluated 2 viscoelastic devices, thromboelastography (TEG) and Viscoelastic Coagulation Monitor (VCM), for monitoring clopidogrel in cats in comparison to light transmission aggregometry (LTA).MethodsTwenty-eight healthy cats received clopidogrel for 7 days. Blood was collected at baseline and after treatment for analysis by TEG, VCM, and LTA.ResultsOn LTA, maximum amplitude, slope, and area under the curve (AUC) significantly decreased after treatment (p