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Non-linear association between liver fibrosis scores and viral load in patients with chronic hepatitis B

Non-linear association between liver fibrosis scores and viral load in patients with chronic hepatitis B

Authors :
Gi-Ae Kim
Seung Won Choi
Seungbong Han
Young-Suk Lim
Source :
Clinical and Molecular Hepatology, Vol 30, Iss 4, Pp 793-806 (2024)
Publication Year :
2024
Publisher :
Korean Association for the Study of the Liver, 2024.

Abstract

Background/Aims Serum hepatitis B virus (HBV) DNA levels and non-invasive liver fibrosis scores are significantly associated with hepatocellular carcinoma (HCC) risk in chronic hepatitis B (CHB) patients. Nonetheless, the relationship between HBV DNA levels and liver fibrosis scores is unclear. Methods A historical cohort comprising 6,949 non-cirrhotic Korean CHB patients without significant alanine aminotransferase elevation was investigated. The association of HBV DNA levels with the aspartate aminotransferase to platelet ratio index (APRI) and fibrosis (FIB)-4 score at baseline was analyzed using general linear models. Results In HBeAg-negative patients (n=4,868), HBV DNA levels correlated linearly with both APRI and FIB-4 scores. In contrast, in HBeAg-positive patients (n=2,081), HBV DNA levels correlated inversely with both APRI and FIB-4 scores. Across the entire cohort, a significant non-linear parabolic relationship was identified between HBV DNA levels and fibrosis scores, independent of age and other covariates. Notably, moderate viral loads (6–7 log10 IU/mL) corresponded to the highest APRI and FIB-4 scores (P

Details

Language :
English
ISSN :
22872728 and 2287285X
Volume :
30
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Clinical and Molecular Hepatology
Publication Type :
Academic Journal
Accession number :
edsdoj.99ee7a9021b740b8ad6ab34791fa5418
Document Type :
article
Full Text :
https://doi.org/10.3350/cmh.2024.0252