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HCC-Check: A Novel Diagnostic Tool for Early Detection of Hepatocellular Carcinoma Based on Cytokeratin-1 and Epithelial Membrane Antigen: A Cross-Sectional Study

Authors :
Kareem A. Attallah MSc
Mohamed S. Albannan PhD
Khaled Farid MD, PhD
Sherine M. Rizk PhD
Nevine Fathy PhD
Source :
Technology in Cancer Research & Treatment, Vol 23 (2024)
Publication Year :
2024
Publisher :
SAGE Publishing, 2024.

Abstract

Background: Hepatocellular carcinoma is frequently diagnosed in advanced stages, leading to a poorer prognosis. Therefore, early diagnosis and identification of biomarkers may significantly improve outcomes. Methods: This cross-sectional study enrolled 486 participants distributed among 3 groups: F1 to F3 = 184, F4 = 183, and hepatocellular carcinoma = 119. Liver fibrosis staging was performed using FibroScan, while imaging features were used for hepatocellular carcinoma detection. Epithelial membrane antigen and cytokeratin-1 levels in serum were quantified through Western blot and ELISA, respectively. Results: Patients diagnosed with hepatocellular carcinoma exhibited significantly elevated levels of epithelial membrane antigen and cytokeratin-1 compared to non-hepatocellular carcinoma patients, with a highly significant statistical difference ( P

Details

Language :
English
ISSN :
15330338
Volume :
23
Database :
Directory of Open Access Journals
Journal :
Technology in Cancer Research & Treatment
Publication Type :
Academic Journal
Accession number :
edsdoj.9a1ae8bbb6bd4057a500f1968c5f8820
Document Type :
article
Full Text :
https://doi.org/10.1177/15330338241234790