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Synthesis and Anticancer Evaluations of Novel Thiazole Derivatives Derived from 4-Phenylthiazol-2-amine

Authors :
Amira E. M. Abdallah
Rafat M. Mohareb
Maher H. E. Helal
Germeen J. Mofeed
Source :
Acta Chimica Slovenica, Vol 68, Iss 3, Pp 604-616 (2021)
Publication Year :
2021
Publisher :
Slovenian Chemical Society, 2021.

Abstract

Many novel thiazole derivatives were designed and synthesized using 4-phenylthiazol-2-amine. The reactivity of the latter compound toward different chemical reagents was studied. The structure of the newly synthesized compounds was established based on elemental analysis and spectral data. Furthermore, twenty compounds of the synthesized systems were selected and evaluated in (µM) as significant anticancer agents towards three human cancer cell lines [MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer)] and normal fibroblasts human cell line (WI-38). The results showed that compounds 9 and 14a displayed higher effeciency than the reference doxorubicin.

Details

Language :
English
ISSN :
13180207 and 15803155
Volume :
68
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Acta Chimica Slovenica
Publication Type :
Academic Journal
Accession number :
edsdoj.9a4b458fdc745dc9de7f107f2151930
Document Type :
article
Full Text :
https://doi.org/10.17344/acsi.2020.6446