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Synthesis and Anticancer Evaluations of Novel Thiazole Derivatives Derived from 4-Phenylthiazol-2-amine
- Source :
- Acta Chimica Slovenica, Vol 68, Iss 3, Pp 604-616 (2021)
- Publication Year :
- 2021
- Publisher :
- Slovenian Chemical Society, 2021.
-
Abstract
- Many novel thiazole derivatives were designed and synthesized using 4-phenylthiazol-2-amine. The reactivity of the latter compound toward different chemical reagents was studied. The structure of the newly synthesized compounds was established based on elemental analysis and spectral data. Furthermore, twenty compounds of the synthesized systems were selected and evaluated in (µM) as significant anticancer agents towards three human cancer cell lines [MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer)] and normal fibroblasts human cell line (WI-38). The results showed that compounds 9 and 14a displayed higher effeciency than the reference doxorubicin.
Details
- Language :
- English
- ISSN :
- 13180207 and 15803155
- Volume :
- 68
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Acta Chimica Slovenica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9a4b458fdc745dc9de7f107f2151930
- Document Type :
- article
- Full Text :
- https://doi.org/10.17344/acsi.2020.6446