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Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice

Authors :
Alexa N. Roth
Emily W. Helm
Carmen Mirabelli
Erin Kirsche
Jonathan C. Smith
Laura B. Eurell
Sourish Ghosh
Nihal Altan-Bonnet
Christiane E. Wobus
Stephanie M. Karst
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Here the authors show that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice and show that lymphocytes affect disease in a dual manner. The data suggests that neonatal mice are a promising model for further studies.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.9a6932ec89e94268872ca25929c2bda7
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-16798-1