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Negri bodies are viral factories with properties of liquid organelles

Authors :
Jovan Nikolic
Romain Le Bars
Zoé Lama
Nathalie Scrima
Cécile Lagaudrière-Gesbert
Yves Gaudin
Danielle Blondel
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Negative strand RNA viruses, such as rabies virus, induce formation of cytoplasmic inclusions for genome replication. Here, Nikolic et al. show that these so-called Negri bodies (NBs) have characteristics of liquid organelles and they identify the minimal protein domains required for NB formation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.9a955e81f9324d589e3ef61679b3fd39
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-00102-9