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Early ART-initiation and longer ART duration reduces HIV-1 proviral DNA levels in children from the CHER trial
- Source :
- AIDS Research and Therapy, Vol 18, Iss 1, Pp 1-12 (2021)
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Abstract Background Reduction of the reservoir of latent HIV-infected cells might increase the possibility of long-term remission in individuals living with HIV. We investigated factors associated with HIV-1 proviral DNA levels in children receiving different antiretroviral therapy (ART) strategies in the children with HIV early antiretroviral therapy (CHER) trial. Methods Infants with HIV < 12 weeks old with CD4% ≥ 25% were randomized in the CHER trial to early limited ART for 40 or 96 weeks (ART-40 W, ART-96 W), or deferred ART (ART-Def). For ART-Def infants or following ART interruption in ART-40 W/ART-96 W, ART was started/re-started for clinical progression or CD4%
- Subjects :
- HIV-1 proviral DNA
Children
Reservoir
ART
CHER
Immunologic diseases. Allergy
RC581-607
Subjects
Details
- Language :
- English
- ISSN :
- 17426405
- Volume :
- 18
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- AIDS Research and Therapy
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9bedca26bec5403c8510741eb07e3ca4
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12981-021-00389-1