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Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines

Authors :
Isabelle Rose Leo
Luay Aswad
Matthias Stahl
Elena Kunold
Frederik Post
Tom Erkers
Nona Struyf
Georgios Mermelekas
Rubin Narayan Joshi
Eva Gracia-Villacampa
Päivi Östling
Olli P. Kallioniemi
Katja Pokrovskaja Tamm
Ioannis Siavelis
Janne Lehtiö
Mattias Vesterlund
Rozbeh Jafari
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Childhood acute lymphoblastic leukemia is characterised by a range of genetic aberrations. Here, the authors use multi-omics profiling of ALL cell lines to connect molecular phenotypes and drug responses to provide an interactive resource of drug sensitivity.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.9c69031e6a7f4af09b4fad9d64e4c2b5
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-29224-5