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Value of Neurofilament Light Chain as a Biomarker in Peripheral Neuropathy
- Source :
- Zhongguo quanke yixue, Vol 25, Iss 32, Pp 3977-3983 (2022)
- Publication Year :
- 2022
- Publisher :
- Chinese General Practice Publishing House Co., Ltd, 2022.
-
Abstract
- Neurofilament light chain (NfL) has been identified as a biomarker of axonal injury in a variety of central nervous system diseases. The value of NfL as a biomarker in peripheral neuropathy has gained increasing attention. We reviewed the relationships of serum NfL with and the dynamics of axonal injury in various immune-mediated peripheral neuropathies (such as Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy), hereditary peripheral neuropathy, drug-induced peripheral neuropathies and diabetic peripheral neuropathy, and drew a conclusion after a comprehensive analysis: the quantified NfL may be used as a promising biomarker to monitor disease activity, assess short- and long-term prognosis, and also as a potential biomarker for clinical trials and monitoring treatment response.
Details
- Language :
- Chinese
- ISSN :
- 10079572
- Volume :
- 25
- Issue :
- 32
- Database :
- Directory of Open Access Journals
- Journal :
- Zhongguo quanke yixue
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9ca7636c5f94a549f37fed3b9f024cb
- Document Type :
- article
- Full Text :
- https://doi.org/10.12114/j.issn.1007-9572.2022.0571