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Photodynamic Therapy for Atherosclerosis

Authors :
Wiktoria Mytych
Dorota Bartusik-Aebisher
Aleksandra Łoś
Klaudia Dynarowicz
Angelika Myśliwiec
David Aebisher
Source :
International Journal of Molecular Sciences, Vol 25, Iss 4, p 1958 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Atherosclerosis, which currently contributes to 31% of deaths globally, is of critical cardiovascular concern. Current diagnostic tools and biomarkers are limited, emphasizing the need for early detection. Lifestyle modifications and medications form the basis of treatment, and emerging therapies such as photodynamic therapy are being developed. Photodynamic therapy involves a photosensitizer selectively targeting components of atherosclerotic plaques. When activated by specific light wavelengths, it induces localized oxidative stress aiming to stabilize plaques and reduce inflammation. The key advantage lies in its selective targeting, sparing healthy tissues. While preclinical studies are encouraging, ongoing research and clinical trials are crucial for optimizing protocols and ensuring long-term safety and efficacy. The potential combination with other therapies makes photodynamic therapy a versatile and promising avenue for addressing atherosclerosis and associated cardiovascular disease. The investigations underscore the possibility of utilizing photodynamic therapy as a valuable treatment choice for atherosclerosis. As advancements in research continue, photodynamic therapy might become more seamlessly incorporated into clinical approaches for managing atherosclerosis, providing a blend of efficacy and limited invasiveness.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
25
Issue :
4
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.9d1adcd1ce3a499899f6db65189f2fa4
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms25041958