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Evaluation of topical methylene blue nanoemulsion for wound healing in diabetic mice
- Source :
- Pharmaceutical Biology, Vol 61, Iss 1, Pp 1462-1473 (2023)
- Publication Year :
- 2023
- Publisher :
- Taylor & Francis Group, 2023.
-
Abstract
- AbstractContext Diabetic wounds (DW) are a complication of diabetes and slow wound healing is the main manifestation. Methylene blue (MB) has been shown to exhibit therapeutic effects on diabetes-related diseases.Objective To investigate the mechanisms of action of MB-nanoemulsion (NE) in the treatment of DW.Materials and methods The concentration of MB-NE used in the in vivo and in vitro experiments was 0.1 mg/mL. Streptozocin-induced diabetic mice were used as models. The mice were separated into nondiabetic, diabetic, MB-NE treated, and NE-treated groups. Intervention of high glucose-induced human umbilical vein endothelial cells using MB-NE. The mechanism by which MB-NE promotes DW healing is investigated by combining histological analysis, immunofluorescence analysis, TUNEL and ROS assays and western blotting.Results In diabetic mice, the MB-NE accelerated DW healing (p
- Subjects :
- Diabetic wound
Nrf2
inhibit apoptosis
Therapeutics. Pharmacology
RM1-950
Subjects
Details
- Language :
- English
- ISSN :
- 13880209 and 17445116
- Volume :
- 61
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Pharmaceutical Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9d7f313c14b52b86045e082854262
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/13880209.2023.2254341