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Sex Differences in Protein Biomarkers and Measures of Fat Distribution

Authors :
Mariana F. Ramirez
Abigail S. Pan
Juhi K. Parekh
Ndidi Owunna
Paul Courchesne
Martin G. Larson
Daniel Levy
Joanne M. Murabito
Jennifer E. Ho
Emily S. Lau
Source :
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 22 (2024)
Publication Year :
2024
Publisher :
Wiley, 2024.

Abstract

Background Sex differences in obesity and fat distribution may in part explain differences in cardiovascular risk in men versus women. We sought to examine sex differences in the associations of obesity and adiposity measures with cardiovascular disease–related protein biomarkers. Methods and Results In a cross‐sectional observational cohort study, we examined whether the association of obesity (body mass index [BMI] and waist circumference) and adiposity measures (visceral adipose tissue) with biomarkers demonstrates effect modification by sex using multiplicative interaction terms in multivariable linear regression models. Among 3143 participants (mean age, 50 years; 49% women), sex modified the association of BMI, waist circumference, and visceral adipose tissue with cardiovascular disease–related protein biomarkers (7 for BMI, 3 for waist circumference, and 23 for visceral adipose tissue, false discovery rate [FDR]‐qint

Details

Language :
English
ISSN :
20479980
Volume :
13
Issue :
22
Database :
Directory of Open Access Journals
Journal :
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.9d98387cdbf949fba5fe7324c74c912c
Document Type :
article
Full Text :
https://doi.org/10.1161/JAHA.124.000223