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Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation
- Source :
- Haematologica, Vol 94, Iss 11 (2009)
- Publication Year :
- 2009
- Publisher :
- Ferrata Storti Foundation, 2009.
-
Abstract
- Analysis of donor chimerism is an important diagnostic tool to assess the risk of relapse after allogeneic stem cell transplantation, especially in patients lacking a specific marker suitable for monitoring of minimal residual disease. We prospectively investigated the predictive value of donor chimerism analyses in sorted CD34+ peripheral blood cells in 90 patients with acute leukemia and myelodysplastic syndrome. The cumulative incidence of relapse after four years was significantly increased in cases with decreasing or incomplete CD34+ donor chimerism (57% vs. 18%, p=0.0001). Multivariate analysis confirmed decreasing CD34+ donor chimerism as an independent predictor of relapse and inferior survival. The interval between a decrease of CD34+ chimerism of less than 80% and hematologic relapse was 61 days (range 0–567). Monitoring of CD34+ donor chimerism in the peripheral blood allows prediction of imminent relapse after allogeneic stem cell transplantation even when a disease-specific marker is lacking.
- Subjects :
- Diseases of the blood and blood-forming organs
RC633-647.5
Subjects
Details
- Language :
- English
- ISSN :
- 03906078 and 15928721
- Volume :
- 94
- Issue :
- 11
- Database :
- Directory of Open Access Journals
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9dc32e9f7c1f4c508640c1704f99d723
- Document Type :
- article
- Full Text :
- https://doi.org/10.3324/haematol.2009.007765