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Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

Authors :
Pradeep Natarajan
Gina M. Peloso
Seyedeh Maryam Zekavat
May Montasser
Andrea Ganna
Mark Chaffin
Amit V. Khera
Wei Zhou
Jonathan M. Bloom
Jesse M. Engreitz
Jason Ernst
Jeffrey R. O’Connell
Sanni E. Ruotsalainen
Maris Alver
Ani Manichaikul
W. Craig Johnson
James A. Perry
Timothy Poterba
Cotton Seed
Ida L. Surakka
Tonu Esko
Samuli Ripatti
Veikko Salomaa
Adolfo Correa
Ramachandran S. Vasan
Manolis Kellis
Benjamin M. Neale
Eric S. Lander
Goncalo Abecasis
Braxton Mitchell
Stephen S. Rich
James G. Wilson
L. Adrienne Cupples
Jerome I. Rotter
Cristen J. Willer
Sekar Kathiresan
NHLBI TOPMed Lipids Working Group
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Common genetic variants associated with plasma lipids have been extensively studied for a better understanding of common diseases. Here, the authors use whole-genome sequencing of 16,324 individuals to analyze rare variant associations and to determine their monogenic and polygenic contribution to lipid traits.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.9e3763d9201a473097a59d1dfd1ef3d8
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-05747-8