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Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- The activation of TGF-β signaling has been implicated in cancer metastasis. Here, the authors show that OTUD1 suppresses metastasis by antagonizing the TGF-β pathway via the deubiquitination of SMAD7, and its loss correlates with poor prognosis in breast cancer.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9f4c20d0b034062b275d5bddb7b2a17
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-017-02029-7