Back to Search
Start Over
Multiorgan Toxicity from Dual Checkpoint Inhibitor Therapy, Resulting in a Complete Response—A Case Report
- Source :
- Medicina, Vol 60, Iss 7, p 1129 (2024)
- Publication Year :
- 2024
- Publisher :
- MDPI AG, 2024.
-
Abstract
- Immunotherapy treatment with checkpoint inhibitors (ICIs) has led to a breakthrough in the treatment of oncological diseases. Despite its clinical effectiveness, this treatment differs from others, such as cytotoxic chemotherapy, in that it causes immune-related adverse events. This type of toxicity can affect any organ or organ system of the body. We present a literature review and a rare clinical case from our clinical practice, in which a patient with metastatic clear cell renal carcinoma was treated with a single dose of dual checkpoint blockade (cytotoxic T-lymphocyte-4 (CTLA-4) and programmed death-1 (PD-1)) and simultaneously diagnosed with colitis, hepatitis, and nephritis. After early immunosuppressive treatment with the glucocorticoids, complete organ function recovery was achieved. The follow-up revealed a sustained complete response lasting more than a year.
Details
- Language :
- English
- ISSN :
- 16489144 and 1010660X
- Volume :
- 60
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Medicina
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9f79bd5c2cd948aabd7295369a35ad5a
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/medicina60071129