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Multiorgan Toxicity from Dual Checkpoint Inhibitor Therapy, Resulting in a Complete Response—A Case Report

Authors :
Skaistė Astašauskaitė
Rita Kupčinskaitė-Noreikienė
Inga Zaborienė
Rūta Vaičiūnienė
Tomas Vanagas
Darius Pranys
Lina Poškienė
Elona Juozaitytė
Source :
Medicina, Vol 60, Iss 7, p 1129 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Immunotherapy treatment with checkpoint inhibitors (ICIs) has led to a breakthrough in the treatment of oncological diseases. Despite its clinical effectiveness, this treatment differs from others, such as cytotoxic chemotherapy, in that it causes immune-related adverse events. This type of toxicity can affect any organ or organ system of the body. We present a literature review and a rare clinical case from our clinical practice, in which a patient with metastatic clear cell renal carcinoma was treated with a single dose of dual checkpoint blockade (cytotoxic T-lymphocyte-4 (CTLA-4) and programmed death-1 (PD-1)) and simultaneously diagnosed with colitis, hepatitis, and nephritis. After early immunosuppressive treatment with the glucocorticoids, complete organ function recovery was achieved. The follow-up revealed a sustained complete response lasting more than a year.

Details

Language :
English
ISSN :
16489144 and 1010660X
Volume :
60
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Medicina
Publication Type :
Academic Journal
Accession number :
edsdoj.9f79bd5c2cd948aabd7295369a35ad5a
Document Type :
article
Full Text :
https://doi.org/10.3390/medicina60071129