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Bacterial outer membrane vesicle based versatile nanosystem boosts the efferocytosis blockade triggered tumor-specific immunity

Authors :
Wan-Ru Zhuang
Yunfeng Wang
Weidong Nie
Yao Lei
Chao Liang
Jiaqi He
Liping Zuo
Li-Li Huang
Hai-Yan Xie
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Efferocytosis inhibition leads to the release of immunogenic contents into the tumor microenvironment. Here the authors developed a nanosystem that inhibits MerTK-mediated efferocytosis and captures tumor-associated agents to enhance antitumour immunity.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b029de03d1dd487c8d91237d991049a2
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-37369-0