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Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes

Authors :
Hanno Schmidt
Travis C. Collier
Mark J. Hanemaaijer
Parker D. Houston
Yoosook Lee
Gregory C. Lanzaro
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Genetic variation in natural populations could represent gene drive resistant alleles, preventing successful application for population management. Here the authors survey 1280 genomes from three mosquito species and concludes natural variation will not be detrimental to deploying gene drive technology.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b0a39060fec94d51a16902c1f33c8a06
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-15204-0