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USP11 controls R-loops by regulating senataxin proteostasis

Authors :
Mateusz Jurga
Arwa A. Abugable
Alastair S. H. Goldman
Sherif F. El-Khamisy
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

DNA:RNA hybrids (R-loops) are products of transcription that impact genome integrity and gene expression. Here the authors reveal a mechanism for regulating R-loops in a ubiquitination-dependent manner controlled by the activities of USP11 and KEAP1

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b0bfd4248dd4385a038034986f146a7
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-25459-w