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Development of targeted therapies in treatment of glioblastoma
- Source :
- Cancer Biology & Medicine, Vol 12, Iss 3, Pp 223-237 (2015)
- Publication Year :
- 2015
- Publisher :
- China Anti-Cancer Association, 2015.
-
Abstract
- Glioblastoma (GBM) is a type of tumor that is highly lethal despite maximal therapy. Standard therapeutic approaches provide modest improvement in progression-free and overall survival, necessitating the investigation of novel therapies. Oncologic therapy has recently experienced a rapid evolution toward "targeted therapy", with drugs directed against specific targets which play essential roles in the proliferation, survival, and invasiveness of GBM cells, including numerous molecules involved in signal transduction pathways. Inhibitors of these molecules have already entered or are undergoing clinical trials. However, significant challenges in their development remain because several preclinical and clinical studies present conflicting results. In this article, we will provide an up-to-date review of the current targeted therapies in GBM.
Details
- Language :
- English
- ISSN :
- 20953941
- Volume :
- 12
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Cancer Biology & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b0ff953aa53140479af5a9653cab316e
- Document Type :
- article
- Full Text :
- https://doi.org/10.7497/j.issn.2095-3941.2015.0020