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Early life gut microbiota sustains liver-resident natural killer cells maturation via the butyrate-IL-18 axis

Authors :
Panpan Tian
Wenwen Yang
Xiaowei Guo
Tixiao Wang
Siyu Tan
Renhui Sun
Rong Xiao
Yuzhen Wang
Deyan Jiao
Yachen Xu
Yanfei Wei
Zhuanchang Wu
Chunyang Li
Lifen Gao
Chunhong Ma
Xiaohong Liang
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Liver-resident natural killer cells develop locally and have multiple immunological roles in situ. Here the authors investigate the gut-liver axis and show the impact of the intestinal microbiota on the development of liver-resident natural killer cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b1710b6339d4a4d9456101338368e42
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-37419-7