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Immunogenicity of two-dose and three-dose vaccination schedules with Sabin inactivated poliovirus vaccine in China: An open-label, randomized, controlled trial
- Source :
- The Lancet Regional Health. Western Pacific, Vol 10, Iss , Pp 100133- (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Background: We assessed immunogenicity of three-dose and two-dose immunization schedules with a Sabin-strain inactivated poliovirus vaccine (sIPV) produced by one Chinese vaccine manufacturer. Methods: This was an open label, randomized, controlled trial conducted in 16 vaccination clinics in Shandong province. Infants were allocated randomly to either a 3-dose study arm (sIPV administered at 2, 3, and 4 months of age) or a 2-dose arm (sIPV administered at 4 and 8–11 months of age). Poliovirus neutralizing antibodies were measured in sera collected prior to the first sIPV dose and one month after the last dose. Findings: We enrolled 560 infants; 536 (95.7%) completed the study. Final seropositivity rates were >98% for all three serotypes in both study arms. There were no statistically significant differences in seropositivity between the 2-dose and the 3-dose schedule. Final median reciprocal titres of polio antibodies were high overall (>1:768 for all serotypes) and statistically significantly higher in 2-dose recipients compared with 3-dose recipients (p
Details
- Language :
- English
- ISSN :
- 26666065
- Volume :
- 10
- Issue :
- 100133-
- Database :
- Directory of Open Access Journals
- Journal :
- The Lancet Regional Health. Western Pacific
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b20ec2696b7e4edc9fab603bdfc2535f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.lanwpc.2021.100133