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Advanced materials for management of immune-related adverse events induced by immune checkpoint inhibitors

Authors :
Lingnan Zheng
Xi Yang
Yuanfeng Wei
Jia You
Huawei Li
Jinfeng Liao
Cheng Yi
Source :
Materials & Design, Vol 219, Iss , Pp 110738- (2022)
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

Immune checkpoint blockade (ICB) therapy has revolutionized the treatment of various types of cancer. However, even promising systemically administered ICB agents can cause immune-related adverse events (irAEs). The management of irAEs has been a significant concern. In addition to the risk of compromised immune function with corticosteroids and other immunomodulatory regimens used to treat irAEs, the complex mechanisms of irAEs make management of the “off-target” effects extremely challenging. Various materials with high biocompatibility, controllable degradability, and the ability for local and targeted delivery and controlled and sustained release of drugs have been explored to limit irAEs. Herein, we briefly review the fundamental mechanisms and clinical applications of immune checkpoint inhibitors and the potential mechanisms and clinical treatment of irAEs. We also highlight the application of emerging materials in the management of irAEs through “prevention” and “treatment”.

Details

Language :
English
ISSN :
02641275
Volume :
219
Issue :
110738-
Database :
Directory of Open Access Journals
Journal :
Materials & Design
Publication Type :
Academic Journal
Accession number :
edsdoj.b268b69409644f4996c4b913dd549ed7
Document Type :
article
Full Text :
https://doi.org/10.1016/j.matdes.2022.110738