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A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Rebelo-Guiomar et al. unveil late stage assembly intermediates of the human mitochondrial ribosome by inactivating the methyltransferase MRM2 in cells. Absence of MRM2 impairs organismal homeostasis, while its catalytic activity is dispensable for mitoribosomal biogenesis.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 35583967
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b26a6648dba14e5181a35583967acaa7
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-28503-5