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FIT-based risk-stratification model effectively screens colorectal neoplasia and early-onset colorectal cancer in Chinese population: a nationwide multicenter prospective study

Authors :
Shengbing Zhao
Shuling Wang
Peng Pan
Tian Xia
Rundong Wang
Quancai Cai
Xin Chang
Fan Yang
Lun Gu
Zixuan He
Jiayi Wu
Qianqian Meng
Tongchang Wang
Qiwen Fang
Xiaomei Mou
Honggang Yu
Jinghua Zheng
Cheng Bai
Yingbin Zou
Dongfeng Chen
Xiaoping Zou
Xu Ren
Leiming Xu
Ping Yao
Guangsu Xiong
Xu Shu
Tong Dang
Li Zhang
Wen Wang
Shengchao Kang
Hongfei Cao
Aixia Gong
Jun Li
Heng Zhang
Yiqi Du
Zhaoshen Li
Yu Bai
Gastrointestinal Early Cancer Prevention & Treatment Alliance of China (GECA)
Source :
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-6 (2022)
Publication Year :
2022
Publisher :
BMC, 2022.

Abstract

Abstract No fully validated risk-stratification strategies have been established in China where colonoscopies resources are limited. We aimed to develop and validate a fecal immunochemical test (FIT)-based risk-stratification model for colorectal neoplasia (CN); 10,164 individuals were recruited from 175 centers nationwide and were randomly allocated to the derivation (n = 6776) or validation cohort (n = 3388). Multivariate logistic analyses were performed to develop the National Colorectal Polyp Care (NCPC) score, which formed the risk-stratification model along with FIT. The NCPC score was developed from eight independent predicting factors and divided into three levels: low risk (LR 0–14), intermediate risk (IR 15–17), and high risk (HR 18–28). Individuals with IR or HR of NCPC score or FIT+ were classified as increased-risk individuals in the risk-stratification model and were recommended for colonoscopy. The IR/HR of NCPC score showed a higher prevalence of CNs (21.8%/32.8% vs. 11.0%, P

Details

Language :
English
ISSN :
17568722
Volume :
15
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Hematology & Oncology
Publication Type :
Academic Journal
Accession number :
edsdoj.b28f365d29a5465aaf50898d0bc79a65
Document Type :
article
Full Text :
https://doi.org/10.1186/s13045-022-01378-1