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Optimization of the reaction conditions for the synthesis of 2,3,5-trimethylpyridine from 3-amino-2-methylpropenal and methylethylketone
- Source :
- Journal of the Serbian Chemical Society, Vol 87, Iss 10, Pp 1117-1123 (2022)
- Publication Year :
- 2022
- Publisher :
- Serbian Chemical Society, 2022.
-
Abstract
- The influence of temperature, reaction time, and type of the catalyst on the yield of the 2,3,5-trimethylpyridine (collidine) from 3-amino-2-methylpropenal and methylethylketone was investigated. 3-Amino-2-methylpropenal was synthesized from 3-ethoxy-2-methylacrolein previously synthesized from methylmalondialdehyde tetraethyl acetal, obtained from triethyl orthoformate and propenyl ether. The optimal conditions for the investigated synthesis were temperature of 150 °C, reaction time 24 h, and the CH3COOH/pTsOH catalyst. This synthesis is the first successful attempt to synthesize 2,3,5-trimethylpyridine in an acid medium.
- Subjects :
- cyclic condensation
gc-ms
side reactions
Chemistry
QD1-999
Subjects
Details
- Language :
- English
- ISSN :
- 03525139 and 18207421
- Volume :
- 87
- Issue :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of the Serbian Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b2bef4e08f374877b135fdc5f432e39d
- Document Type :
- article
- Full Text :
- https://doi.org/10.2298/JSC210918042U