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SARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell model

Authors :
Christin Mache
Jessica Schulze
Gudrun Holland
Daniel Bourquain
Jean-Marc Gensch
Djin-Ye Oh
Andreas Nitsche
Ralf Dürrwald
Michael Laue
Thorsten Wolff
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Human alveolar epithelial lentivirus immortalized cells are very permissive for human coronaviruses and influenza A viruses, provided a suitable model for such infections of the lower respiratory tract as shown by reduced propagation of the SARS-CoV-2 Omicron variant.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.b36d9857061a44a780e2afc9fa7c47c0
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-04068-3