Back to Search Start Over

White matter microstructure and its relation to clinical features of obsessive–compulsive disorder: findings from the ENIGMA OCD Working Group

White matter microstructure and its relation to clinical features of obsessive–compulsive disorder: findings from the ENIGMA OCD Working Group

Authors :
Fabrizio Piras
Federica Piras
Yoshinari Abe
Sri Mahavir Agarwal
Alan Anticevic
Stephanie Ameis
Paul Arnold
Nerisa Banaj
Núria Bargalló
Marcelo C. Batistuzzo
Francesco Benedetti
Jan-Carl Beucke
Premika S. W. Boedhoe
Irene Bollettini
Silvia Brem
Anna Calvo
Kang Ik Kevin Cho
Valentina Ciullo
Sara Dallaspezia
Erin Dickie
Benjamin Adam Ely
Siyan Fan
Jean-Paul Fouche
Patricia Gruner
Deniz A. Gürsel
Tobias Hauser
Yoshiyuki Hirano
Marcelo Q. Hoexter
Mariangela Iorio
Anthony James
Y. C. Janardhan Reddy
Christian Kaufmann
Kathrin Koch
Peter Kochunov
Jun Soo Kwon
Luisa Lazaro
Christine Lochner
Rachel Marsh
Akiko Nakagawa
Takashi Nakamae
Janardhanan C. Narayanaswamy
Yuki Sakai
Eiji Shimizu
Daniela Simon
Helen Blair Simpson
Noam Soreni
Philipp Stämpfli
Emily R. Stern
Philip Szeszko
Jumpei Takahashi
Ganesan Venkatasubramanian
Zhen Wang
Je-Yeon Yun
ENIGMA OCD Working Group
Dan J. Stein
Neda Jahanshad
Paul M. Thompson
Odile A. van den Heuvel
Gianfranco Spalletta
Source :
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Publication Year :
2021
Publisher :
Nature Publishing Group, 2021.

Abstract

Abstract Microstructural alterations in cortico-subcortical connections are thought to be present in obsessive–compulsive disorder (OCD). However, prior studies have yielded inconsistent findings, perhaps because small sample sizes provided insufficient power to detect subtle abnormalities. Here we investigated microstructural white matter alterations and their relation to clinical features in the largest dataset of adult and pediatric OCD to date. We analyzed diffusion tensor imaging metrics from 700 adult patients and 645 adult controls, as well as 174 pediatric patients and 144 pediatric controls across 19 sites participating in the ENIGMA OCD Working Group, in a cross-sectional case-control magnetic resonance study. We extracted measures of fractional anisotropy (FA) as main outcome, and mean diffusivity, radial diffusivity, and axial diffusivity as secondary outcomes for 25 white matter regions. We meta-analyzed patient-control group differences (Cohen’s d) across sites, after adjusting for age and sex, and investigated associations with clinical characteristics. Adult OCD patients showed significant FA reduction in the sagittal stratum (d = −0.21, z = −3.21, p = 0.001) and posterior thalamic radiation (d = −0.26, z = −4.57, p

Details

Language :
English
ISSN :
21583188
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Translational Psychiatry
Publication Type :
Academic Journal
Accession number :
edsdoj.b36da10d51bf4965b4db2670ad87a177
Document Type :
article
Full Text :
https://doi.org/10.1038/s41398-021-01276-z