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The situations and strategies of amyloid⁃β⁃directed passive immunotherapy for Alzheimer's disease
- Source :
- Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 19, Iss 12, Pp 987-993 (2019)
- Publication Year :
- 2019
- Publisher :
- Tianjin Huanhu Hospital, 2019.
-
Abstract
- It is widely believed that amyloid β⁃protein (Aβ) plays a core role in the pathogenesis of Alzheimer's disease (AD). Thus A β is one of main targets in the therapeutic explorations for AD. Currently, clearance of A β by passive immunotherapy is an important strategy for the treatment of AD. However, no consistent conclusions have been obtained from various clinical trails. We summarize the current situations of A β⁃directed passive immunotherapy for AD, and speculate that the failure of A β⁃directed passive immunotherapy for AD may be related to the intrinsic characteristics of A β⁃IgG glycosylation. Therefore, modifications of N ⁃ glycosylation on the Fc domain of A β⁃IgG and using a sequential administration mode of proinflammation⁃antiinflammation may be an effective strategy for passive immunotherapy for AD. DOI:10.3969/j.issn.1672⁃6731.2019.12.014
Details
- Language :
- English, Chinese
- ISSN :
- 16726731
- Volume :
- 19
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Chinese Journal of Contemporary Neurology and Neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b3bc2befe0b4f76b791dae2ec0c52b6
- Document Type :
- article