Back to Search Start Over

Antimicrobial Activities and Mode of Flavonoid Actions

Authors :
Amal Thebti
Ahmed Meddeb
Issam Ben Salem
Coulibaly Bakary
Sami Ayari
Farhat Rezgui
Khadija Essafi-Benkhadir
Abdellatif Boudabous
Hadda-Imene Ouzari
Source :
Antibiotics, Vol 12, Iss 2, p 225 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

The emergence of antibiotics-resistant bacteria has been a serious concern for medical professionals over the last decade. Therefore, developing new and effective antimicrobials with modified or different modes of action is a continuing imperative. In this context, our study focuses on evaluating the antimicrobial activity of different chemically synthesized flavonoids (FLAV) to guide the chemical synthesis of effective antimicrobial molecules. A set of 12 synthesized molecules (4 chalcones, 4 flavones and 4 flavanones), bearing substitutions with chlorine and bromine groups at the C6′ position and methoxy group at the C4′ position of the B-ring were evaluated for antimicrobial activity toward 9 strains of Gram-positive and Gram-negative bacteria and 3 fungal strains. Our findings showed that most tested FLAV exhibited moderate to high antibacterial activity, particularly against Staphylococcus aureus with minimum inhibitory concentrations (MIC) between the range of 31.25 and 125 μg/mL and that chalcones were more efficient than flavones and flavanones. The examined compounds were also active against the tested fungi with a strong structure-activity relationship (SAR). Interestingly, leakage measurements of the absorbent material at 260 nm and scanning electron microscopy (SEM) demonstrated that the brominated chalcone induced a significant membrane permeabilization of S. aureus.

Details

Language :
English
ISSN :
20796382
Volume :
12
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Antibiotics
Publication Type :
Academic Journal
Accession number :
edsdoj.b3c16d3e99f84b7693bb08868ab31b9b
Document Type :
article
Full Text :
https://doi.org/10.3390/antibiotics12020225