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Comparison of Antioxidant and Anticancer Properties of Soft Coral-Derived Sinularin and Dihydrosinularin

Authors :
Sheng-Chieh Wang
Ruei-Nian Li
Li-Ching Lin
Jen-Yang Tang
Jui-Hsin Su
Jyh-Horng Sheu
Hsueh-Wei Chang
Source :
Molecules, Vol 26, Iss 13, p 3853 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Marine natural products are abundant resources for antioxidants, but the antioxidant property of the soft corals-derived sinularin and dihydrosinularin were unknown. This study aimed to assess antioxidant potential and antiproliferation effects of above compounds on cancer cells, and to investigate the possible relationships between them. Results show that sinularin and dihydrosinularin promptly reacted with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl (•OH), demonstrating a general radical scavenger activity. Sinularin and dihydrosinularin also show an induction for Fe+3-reduction and Fe+2-chelating capacity which both strengthen their antioxidant activities. Importantly, sinularin shows higher antioxidant properties than dihydrosinularin. Moreover, 24 h ATP assays show that sinularin leads to higher antiproliferation of breast, lung, and liver cancer cells than dihydrosinularin. Therefore, the differential antioxidant properties of sinularin and dihydrosinularin may contribute to their differential anti-proliferation of different cancer cells.

Details

Language :
English
ISSN :
14203049
Volume :
26
Issue :
13
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.b3e838ba6c3a41f2826da3e39070a956
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules26133853