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Development of a rat model of lymphedema and the implantation of a collagen-based medical device for therapeutic intervention

Authors :
Dung Nguyen
Dimitrios Dionyssiou
Tatiana S. Zaitseva
Anna T. Zhou
Gloria Sue
Peter Deptula
Maxim A. Moroz
Peter Tabada
Stanley G. Rockson
Michael V. Paukshto
Ming-Huei Cheng
Ngan F. Huang
Source :
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Publication Year :
2023
Publisher :
Frontiers Media S.A., 2023.

Abstract

Secondary lymphedema is a common condition among cancer survivors, and treatment strategies to prevent or treat lymphedema are in high demand. The development of novel strategies to diagnose or treat lymphedema would benefit from a robust experimental animal model of secondary lymphedema. The purpose of this methods paper is to describe and summarize our experience in developing and characterizing a rat hindlimb model of lymphedema. Here we describe a protocol to induce secondary lymphedema that takes advantage of micro computed tomography imaging for limb volume measurements and visualization of lymph drainage with near infrared imaging. To demonstrate the utility of this preclinical model for studying the therapeutic benefit of novel devices, we apply this animal model to test the efficacy of a biomaterials-based implantable medical device.

Details

Language :
English
ISSN :
2297055X
Volume :
10
Database :
Directory of Open Access Journals
Journal :
Frontiers in Cardiovascular Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.b4031615f9944b909e6e403a2ad9d359
Document Type :
article
Full Text :
https://doi.org/10.3389/fcvm.2023.1214116