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Cutaneous adverse events of immune checkpoint inhibitor therapy: incidence and types of reactive dermatoses
- Source :
- Journal of Dermatological Treatment, Vol 33, Iss 3, Pp 1691-1695 (2022)
- Publication Year :
- 2022
- Publisher :
- Taylor & Francis Group, 2022.
-
Abstract
- Background Dermatoses are common and potentially serious complications of programmed cell death receptor PD-1 immune checkpoint inhibitor (anti-PD-1 ICI) therapy. Understanding their incidence is necessary to support clinical awareness, diagnosis, and management. Objective To examine the incidence and odds of reported non-cancerous dermatoses in the setting of anti-PD-1 ICI therapy. Methods Cross-sectional study of anti-PD-1 (pembrolizumab or nivolumab) treated patients at a tertiary healthcare institution. Selected dermatologic events following immunotherapy were identified in the electronic medical record. Comparator arm were patients that developed these same dermatoses without receiving anti-PD-1 ICI therapy. Results There were 13.7% (254/1857) patients that developed one of 28 dermatoses. Compared with the general population, patients treated with anti-PD-1 had a greater risk for development of mucositis (OR 65.7, 95% CI 35.0–123.3), xerostomia (OR 11.9, 95% CI 8.4–16.8), pruritus (11.3, 95% CI 8.9–14.3), and lichen planus/lichenoid dermatitis (OR 10.7, 95% CI 5.6–20.7). Conclusions We report the frequency of dermatoses encountered in the setting of ICI therapy, both common (pruritus, rash, vitiligo) and uncommon (scleroderma, urticaria).
- Subjects :
- nivolumab
pembrolizumab
irae
drug reaction
Dermatology
RL1-803
Subjects
Details
- Language :
- English
- ISSN :
- 09546634 and 14711753
- Volume :
- 33
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Dermatological Treatment
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b48bed8195084f659bc2e4430985fb43
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/09546634.2021.1898529