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Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Restoration of normal gene expression is one way to treat monogenic disorders. Here the authors target naturally occurring non-productive alternative splicing using antisense oligonucleotides to promote the production of functional proteins.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b4b17242c1b24dc9905cc03dd97077f2
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-17093-9