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The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer
- Source :
- Pharmaceuticals, Vol 3, Iss 5, Pp 1550-1560 (2010)
- Publication Year :
- 2010
- Publisher :
- MDPI AG, 2010.
-
Abstract
- Epidemiological evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) which act as cyclooxygenase (COX-2) inhibitors may reduce breast cancer incidence by up to 20%. These agents are often taken for pain relief by older women with osteoarthritis. Age is the major risk factor for breast cancer in women with 50% cases being diagnosed in those aged >65 years. NSAIDs reduce serum estradiol by 17% in post-menopausal women and since most of these who develop breast cancers have estrogen receptor positive tumours; this suggests a possible preventative role. Careful use of these agents could provide a strategy for both relief of symptoms of osteoarthritis and also breast cancer prevention. Instead of conducting a randomised trial, proof of efficacy could be from an adequately powered cohort study within the breast screening programme.
Details
- Language :
- English
- ISSN :
- 14248247
- Volume :
- 3
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Pharmaceuticals
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b4c8422bd23647198d8d97b319151fba
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/ph3051550