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Antibiotics with antibiofilm activity – rifampicin and beyond

Authors :
Luís Ferreira
Ema Pos
Daniela Rodrigues Nogueira
Filipa Pinto Ferreira
Ricardo Sousa
Miguel Araújo Abreu
Source :
Frontiers in Microbiology, Vol 15 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

The management of prosthetic joint infections is a complex and multilayered process that is additionally complicated by the formation of bacterial biofilm. Foreign material provides the ideal grounds for the development of an intricate matrix that hinders treatment and creates a difficult environment for antibiotics to act. Surgical intervention is often warranted but requires appropriate adjunctive therapy. Despite available guidelines, several aspects of antibiotic therapy with antibiofilm activity lack clear definition. Given the escalating challenges posed by antimicrobial resistance, extended treatment durations, and tolerance issues, it is essential to ensure that antimicrobials with antibiofilm activity are both potent and diverse. Evidence of biofilm-active drugs is highlighted, and alternatives to classical regimens are further discussed.

Details

Language :
English
ISSN :
1664302X
Volume :
15
Database :
Directory of Open Access Journals
Journal :
Frontiers in Microbiology
Publication Type :
Academic Journal
Accession number :
edsdoj.b4f4f38088ea403c9879a17d4f216706
Document Type :
article
Full Text :
https://doi.org/10.3389/fmicb.2024.1435720