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Nanozyme for tumor therapy: Surface modification matters

Authors :
Guoheng Tang
Jiuyang He
Juewen Liu
Xiyun Yan
Kelong Fan
Source :
Exploration, Vol 1, Iss 1, Pp 75-89 (2021)
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

Abstract As the next generation of artificial enzymes, nanozymes have shown unique properties compared to its natural counterparts, such as stability in harsh environment, low cost, and ease of production and modification, paving the way for its biomedical applications. Among them, tumor catalytic therapy mediated by the generation of reactive oxygen species (ROS) has made great progress mainly from the peroxidase‐like activity of nanozymes. Fe3O4 nanozymes, the earliest type of nanomaterial discovered to possess peroxidase‐like activity, has consequently received wide attention for tumor therapy due to its ROS generation ability and tumor cell killing ability. However, inconsistent results of cytotoxicity were observed between different reports, and some even showed the scavenging of ROS in some cases. By collectively studying these inconsistent outcomes, we raise the question whether surface modification of Fe3O4 nanozymes, either through affecting peroxidase activity or by affecting the biodistribution and intracellular fate, play an important role in its therapeutic effects. This review will go over the fundamental catalytic mechanisms of Fe3O4 nanozymes and recent advances in tumor catalytic therapy, and discuss the importance of surface modification. Employing Fe3O4 nanozymes as an example, we hope to provide an outlook on the improvement of nanozyme‐based antitumor activity.

Details

Language :
English
ISSN :
27662098 and 27668509
Volume :
1
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Exploration
Publication Type :
Academic Journal
Accession number :
edsdoj.b52ecda80b594d58a90ef347ad5cce75
Document Type :
article
Full Text :
https://doi.org/10.1002/EXP.20210005