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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Authors :
Sonia Shah
Albert Henry
Carolina Roselli
Honghuang Lin
Garðar Sveinbjörnsson
Ghazaleh Fatemifar
Åsa K. Hedman
Jemma B. Wilk
Michael P. Morley
Mark D. Chaffin
Anna Helgadottir
Niek Verweij
Abbas Dehghan
Peter Almgren
Charlotte Andersson
Krishna G. Aragam
Johan Ärnlöv
Joshua D. Backman
Mary L. Biggs
Heather L. Bloom
Jeffrey Brandimarto
Michael R. Brown
Leonard Buckbinder
David J. Carey
Daniel I. Chasman
Xing Chen
Xu Chen
Jonathan Chung
William Chutkow
James P. Cook
Graciela E. Delgado
Spiros Denaxas
Alexander S. Doney
Marcus Dörr
Samuel C. Dudley
Michael E. Dunn
Gunnar Engström
Tõnu Esko
Stephan B. Felix
Chris Finan
Ian Ford
Mohsen Ghanbari
Sahar Ghasemi
Vilmantas Giedraitis
Franco Giulianini
John S. Gottdiener
Stefan Gross
Daníel F. Guðbjartsson
Rebecca Gutmann
Christopher M. Haggerty
Pim van der Harst
Craig L. Hyde
Erik Ingelsson
J. Wouter Jukema
Maryam Kavousi
Kay-Tee Khaw
Marcus E. Kleber
Lars Køber
Andrea Koekemoer
Claudia Langenberg
Lars Lind
Cecilia M. Lindgren
Barry London
Luca A. Lotta
Ruth C. Lovering
Jian’an Luan
Patrik Magnusson
Anubha Mahajan
Kenneth B. Margulies
Winfried März
Olle Melander
Ify R. Mordi
Thomas Morgan
Andrew D. Morris
Andrew P. Morris
Alanna C. Morrison
Michael W. Nagle
Christopher P. Nelson
Alexander Niessner
Teemu Niiranen
Michelle L. O’Donoghue
Anjali T. Owens
Colin N. A. Palmer
Helen M. Parry
Markus Perola
Eliana Portilla-Fernandez
Bruce M. Psaty
Regeneron Genetics Center
Kenneth M. Rice
Paul M. Ridker
Simon P. R. Romaine
Jerome I. Rotter
Perttu Salo
Veikko Salomaa
Jessica van Setten
Alaa A. Shalaby
Diane T. Smelser
Nicholas L. Smith
Steen Stender
David J. Stott
Per Svensson
Mari-Liis Tammesoo
Kent D. Taylor
Maris Teder-Laving
Alexander Teumer
Guðmundur Thorgeirsson
Unnur Thorsteinsdottir
Christian Torp-Pedersen
Stella Trompet
Benoit Tyl
Andre G. Uitterlinden
Abirami Veluchamy
Uwe Völker
Adriaan A. Voors
Xiaosong Wang
Nicholas J. Wareham
Dawn Waterworth
Peter E. Weeke
Raul Weiss
Kerri L. Wiggins
Heming Xing
Laura M. Yerges-Armstrong
Bing Yu
Faiez Zannad
Jing Hua Zhao
Harry Hemingway
Nilesh J. Samani
John J. V. McMurray
Jian Yang
Peter M. Visscher
Christopher Newton-Cheh
Anders Malarstig
Hilma Holm
Steven A. Lubitz
Naveed Sattar
Michael V. Holmes
Thomas P. Cappola
Folkert W. Asselbergs
Aroon D. Hingorani
Karoline Kuchenbaecker
Patrick T. Ellinor
Chim C. Lang
Kari Stefansson
J. Gustav Smith
Ramachandran S. Vasan
Daniel I. Swerdlow
R. Thomas Lumbers
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously reported.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b5721b6147184dcfac6753b6e07e56dd
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-13690-5