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Screening of tumor antigens and immunogenic cell death landscapes of prostate adenocarcinoma for exploration of mRNA vaccine

Screening of tumor antigens and immunogenic cell death landscapes of prostate adenocarcinoma for exploration of mRNA vaccine

Authors :
Guopeng Yu
Yuansheng Lin
Jianqing Wang
Lin Zhou
Yingying Lu
Xiang Fei
Xin Gu
Shangqing Song
Jiangyi Wang
Yushan Liu
Qing Yang
Ming Zhan
Seung-Yong Seo
Bin Xu
Source :
Expert Review of Vaccines, Vol 23, Iss 1, Pp 830-844 (2024)
Publication Year :
2024
Publisher :
Taylor & Francis Group, 2024.

Abstract

Background In this study, effective antigens of mRNA vaccine were excavated from the perspective of ICD, and ICD subtypes of PRAD were further distinguished to establish an ICD landscape, thereby determining suitable vaccine recipients.Research design and methods TCGA and MSKCC databases were applied to acquire RNA-seq data and corresponding clinical data of 554 and 131 patients, respectively. GEPIA was employed to measure prognostic indices. Then, a comparison of genetic alterations was performed utilizing cBioPortal, and correlation of identified ICD antigens with immune infiltrating cells was analyzed employing TIMER. Moreover, ICD subtypes were identified by means of consensus cluster, and ICD landscape of PRAD was depicted utilizing graph learning-based dimensional reduction.Results In total, 4 PRAD antigens were identified in PRAD, including FUS, LMNB2, RNPC3, and ZNF700, which had association with adverse prognosis and infiltration of APCs. PRAD patients were classified as two ICD subtypes based on their differences in molecular, cellular, and clinical features. Furthermore, ICD modulators and immune checkpoints were also differentially expressed between two ICD subtype tumors. Finally, the ICD landscape of PRAD showed substantial heterogeneity among individual patients.Conclusions In summary, the research may provide a theoretical foundation for developing mRNA vaccine against PRAD as well as determining appropriate vaccine recipients.

Details

Language :
English
ISSN :
14760584 and 17448395
Volume :
23
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Expert Review of Vaccines
Publication Type :
Academic Journal
Accession number :
edsdoj.b592deaab3745cebab19714e3a33023
Document Type :
article
Full Text :
https://doi.org/10.1080/14760584.2024.2396086