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The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients
- Source :
- Gastroenterology Research and Practice, Vol 2016 (2016)
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Helicobacter pylori (H. pylori, Hp) colonizes the stomachs of approximately 20%–80% of humans throughout the world. The Word Healthy Organization (WHO) classified H. pylori as a group 1 carcinogenic factor in 1994. Recently, an increasing number of studies has shown an association between H. pylori infection and various extragastric diseases. Functional dyspepsia (FD) is considered a biopsychosocial disorder with multifactorial pathogenesis, and studies have shown that infection with CagA-positive H. pylori strains could explain some of the symptoms of functional dyspepsia. Moreover, CagA-positive H. pylori strains have been shown to affect the secretion of several hormones, including 5-HT, ghrelin, dopamine, and gastrin, and altered levels of these hormones might be the cause of the psychological disorders of functional dyspepsia patients. This review describes the mutual effects of H. pylori and hormones in functional dyspepsia and provides new insight into the pathogenesis of functional dyspepsia.
- Subjects :
- Diseases of the digestive system. Gastroenterology
RC799-869
Subjects
Details
- Language :
- English
- ISSN :
- 16876121 and 1687630X
- Volume :
- 2016
- Database :
- Directory of Open Access Journals
- Journal :
- Gastroenterology Research and Practice
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b5d67707e490413cb7889c773a8c9c21
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2016/7150959