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SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung

Authors :
Nanda Kishore Routhu
Narayanaiah Cheedarla
Venkata Satish Bollimpelli
Sailaja Gangadhara
Venkata Viswanadh Edara
Lilin Lai
Anusmita Sahoo
Ayalnesh Shiferaw
Tiffany M. Styles
Katharine Floyd
Stephanie Fischinger
Caroline Atyeo
Sally A. Shin
Sanjeev Gumber
Shannon Kirejczyk
Kenneth H. Dinnon
Pei-Yong Shi
Vineet D. Menachery
Mark Tomai
Christopher B. Fox
Galit Alter
Thomas H. Vanderford
Lisa Gralinski
Mehul S. Suthar
Rama Rao Amara
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Efficient vaccines for SARS-CoV-2 are needed. Here, the authors show that a trimeric form of the receptor-binding domain of SARS-CoV-2 spike adjuvanted with alum-3M-052 protects non-human primates from disease and inhibits infection.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b5e727593c442beadc6bb289092f047
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-23942-y