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TAZ expression as a prognostic indicator in colorectal cancer.

Authors :
Hiu-Fung Yuen
Cian M McCrudden
Yu-Han Huang
Jill M Tham
Xiaoqian Zhang
Qi Zeng
Shu-Dong Zhang
WanJin Hong
Source :
PLoS ONE, Vol 8, Iss 1, p e54211 (2013)
Publication Year :
2013
Publisher :
Public Library of Science (PLoS), 2013.

Abstract

The Hippo pathway restricts the activity of transcriptional coactivators TAZ (WWTR1) and YAP. TAZ and YAP are reported to be overexpressed in various cancers, however, their prognostic significance in colorectal cancers remains unstudied. The expression levels of TAZ and YAP, and their downstream transcriptional targets, AXL and CTGF, were extracted from two independent colon cancer patient datasets available in the Gene Expression Omnibus database, totaling 522 patients. We found that mRNA expressions of both TAZ and YAP were positively correlated with those of AXL and CTGF (p

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
19326203
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
edsdoj.b67df3a4114cafa0a492b343604427
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pone.0054211