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The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- The authors find that the insulin receptor forms dynamic clusters during insulin signaling and that these clusters become dysfunctional in insulin resistance. This dysfunction is partially rescued by metformin, a drug used to treat type 2 diabetes.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b6a27a393d354ad08dc4d2e2cdc0f034
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-35176-7