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Primary sarcomas of the larynx: A report of three cases and literature review

Authors :
Ugrinović Aleksandar
Trivić Aleksandar
Đorđević Vladimir
Tomanović Nada
Folić Miljan
Source :
Srpski Arhiv za Celokupno Lekarstvo, Vol 150, Iss 3-4, Pp 228-232 (2022)
Publication Year :
2022
Publisher :
Serbian Medical Society, 2022.

Abstract

Introduction. Primary sarcomas are uncommonly seen in the larynx and comprise around 1% of all laryngeal malignant tumors. We present three cases of patients with different types of laryngeal sarcomas and discuss about diagnostic and treatment difficulties. Case outline. Each patient presented with hoarseness and shortness of breath. Computed tomography scans showed large transglottic tumors of the larynx with no signs of cervical lymphadenopathy and definitive diagnoses of sarcomas were made by pathologists. Each patient underwent total laryngectomy with clear resection margins. Patient with laryngeal leiomyosarcoma developed large locoregional relapse of malignant disease and pulmonary metastasis four months after surgery and patient with laryngeal osteosarcoma was diagnosed with inoperative locoregional relapse of malignant disease three months after surgery. Both patients died within six months after surgery. On the other hand, patient with laryngeal chondrosarcoma was disease-free during the three-year follow-up. Conclusion. Primary laryngeal sarcomas have low incidence and they differ from squamous cell carcinoma by their biological characteristics and behavior. Radical surgical resection remains the mainstay of treatment with uncertain outcome due to their high potential for recurrence or metastatic spread.

Details

Language :
English, Serbian
ISSN :
03708179 and 24060895
Volume :
150
Issue :
3-4
Database :
Directory of Open Access Journals
Journal :
Srpski Arhiv za Celokupno Lekarstvo
Publication Type :
Academic Journal
Accession number :
edsdoj.b6bf5ed3a11f4d0e8aed1b19ecfbb08a
Document Type :
article
Full Text :
https://doi.org/10.2298/SARH211104008U